Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
نویسندگان
چکیده
منابع مشابه
Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1
BACKGROUND Mother-to-child transmission (MTCT) is the main cause of HIV-1 infection in children worldwide. Given that the C-type lectin receptor, dendritic cell-specific ICAM-grabbing non-integrin-related (DC-SIGNR, also known as CD209L or liver/lymph node-specific ICAM-grabbing non-integrin (L-SIGN)), can interact with pathogens including HIV-1 and is expressed at the maternal-fetal interface,...
متن کاملPrevention of Mother to Child HIV Transmission
In Iran 8% of HIV- infected cases are women. Since most of them are young and in childbearing ages, in case of becoming pregnant and not receiving preventive measures, they can infect their child. Without Preventive measures transmission rate is 15 to 45 percent. Several factors such as sever stage of HIV and AIDS ,CD4 low count, high viral loud, acute retroviral phase, STDs, vaginal delivery, ...
متن کاملMother-to-child transmission of HIV-1.
After reviewing the evidence on the relation of vertical transmission of HIV to stage of infection in the mother, I developed a stochastic model of transmission in which the probability of transmission per week is proportional to the virus load in the mother. The virus load in different stages of the infection is measured by viral RNA levels or tissue culture infectious virus levels in plasma. ...
متن کاملFunctional properties of the HIV-1 subtype C envelope glycoprotein associated with mother-to-child transmission.
Understanding the properties of viruses capable of establishing infection during perinatal transmission of HIV-1 is critical for designing effective means of limiting transmission. We previously demonstrated that the newly transmitted viruses (in infant) were more fit in growth, as imparted by their envelope glycoproteins, than those in their corresponding mothers. Here, we further characterize...
متن کاملSequence evolution of HIV-1 following mother-to-child transmission.
The genetic heterogeneity of HIV-1 poses a major obstacle to vaccine development. Although most horizontally acquired HIV-1 infections are initiated by a single homogeneous virus, marked genetic diversification and evolution occur following transmission. The relative contribution of the antiviral immune response to intrahost viral evolution remains controversial, in part because the sequence of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2009
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0007211